{"id":12346,"date":"2025-06-11T07:41:33","date_gmt":"2025-06-11T07:41:33","guid":{"rendered":"https:\/\/www.pixience.com\/evaluating-the-effectiveness-of-antioxidant-treatments-the-contribution-of-the-c-cube-in-clinical-research\/"},"modified":"2026-02-27T10:15:03","modified_gmt":"2026-02-27T10:15:03","slug":"evaluating-the-effectiveness-of-antioxidant-treatments-the-contribution-of-the-c-cube-in-clinical-research","status":"publish","type":"post","link":"https:\/\/www.pixience.com\/en\/evaluating-the-effectiveness-of-antioxidant-treatments-the-contribution-of-the-c-cube-in-clinical-research\/","title":{"rendered":"Evaluating the effectiveness of antioxidant treatments: the contribution of the C-Cube in clinical research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"12346\" class=\"elementor elementor-12346 elementor-12321\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-82e47b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"82e47b3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b0a8771\" data-id=\"b0a8771\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4b43be1 elementor-widget elementor-widget-spacer\" data-id=\"4b43be1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 17-01-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a65a79 elementor-widget elementor-widget-heading\" data-id=\"8a65a79\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 17-01-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Evaluating the effectiveness of antioxidant treatments: the contribution of the C-Cube in clinical research<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6ff6ec elementor-widget elementor-widget-heading\" data-id=\"f6ff6ec\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Antioxidants &amp; oxidative stress: major cosmetic issues<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4685159 elementor-widget elementor-widget-spacer\" data-id=\"4685159\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ee7e220 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ee7e220\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f1e953d\" data-id=\"f1e953d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eddb9af elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"eddb9af\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 17-01-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" width=\"800\" height=\"800\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO-1024x1024.png\" class=\"attachment-large size-large wp-image-12326\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO-1024x1024.png 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO-300x300.png 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO-150x150.png 150w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO-768x768.png 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/AGE-BIO.png 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e68b2f7\" data-id=\"e68b2f7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b9d3a9 elementor-widget elementor-widget-spacer\" data-id=\"7b9d3a9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f4b14b elementor-widget elementor-widget-text-editor\" data-id=\"3f4b14b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 17-01-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><strong>Antioxidants <\/strong>have become essential active ingredients in cosmetic formulas, especially for their protective effects against <strong>oxidative stress<\/strong>. This phenomenon, caused by an overproduction of free radicals (from pollution, UV rays or aging), is responsible for many skin alterations: pigment spots, loss of radiance, early wrinkles, disorganization of the skin microrelief&#8230; <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-667a381 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"667a381\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-17319a9\" data-id=\"17319a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5186a23 elementor-widget elementor-widget-spacer\" data-id=\"5186a23\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d365ab elementor-widget elementor-widget-text-editor\" data-id=\"0d365ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Antioxidant active ingredients are essential in dermocosmetic formulas, with multiple claims: protection, regeneration, radiance, detox effect&#8230;<\/p>\n<p>To objectify these effects, laboratories must rely on precise, standardised and reliable analysis technologies. This is where <strong>C-Cube Clinical Research<\/strong> becomes interesting. <\/p>\n<p><strong>C-Cube: a precision imager for clinical objectification<\/strong><\/p>\n<p>Designed for clinical research, the <strong>C-Cube<\/strong> combines a calibrated optical system, homogeneous illumination, and <strong>2D color<\/strong> and <strong>3D stereophotometric<\/strong> imaging capabilities. It thus offers a fine visualization of skin structures, with a <strong>margin of error of less than 0.1%.<\/strong> <\/p>\n<p>Standardized, reproducible, and interoperable between study centers, it allows a <strong>rigorous quantitative analysis<\/strong> of the skin effects of antioxidant treatments.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f863a44 elementor-widget__width-initial e-transform elementor-widget elementor-widget-image\" data-id=\"f863a44\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:310,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img width=\"800\" height=\"735\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-1024x941.png\" class=\"attachment-large size-large wp-image-11839\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-1024x941.png 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-300x276.png 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-768x706.png 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-1536x1411.png 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/02\/c-cube_ordi-1-2048x1882.png 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">C-Cube and its software Clinical Research<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be67150 elementor-widget elementor-widget-spacer\" data-id=\"be67150\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bec9305 elementor-widget elementor-widget-heading\" data-id=\"bec9305\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What parameters can be used to objectify the antioxidant effect?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc9213 elementor-widget elementor-widget-text-editor\" data-id=\"6dc9213\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol>\n<li><strong>1. Pigmentation: detection of spots induced by oxidative stress<\/strong><\/li>\n<\/ol>\n<p>Oxidative stress plays a recognized role in the appearance of <strong>pigment spots<\/strong>, especially actinic lentigines. The C-Cube can detect hyperpigmented areas (lentigines, sunspots, etc.) via colorimetric filters and intensity thresholds. This analysis is based on an index correlated with the amount of melanin in the skin.  <\/p>\n<p>This data makes it possible to objectively measure:<\/p>\n<ul>\n<li><strong>Reduction of the surface area or intensity of spots,<\/strong><\/li>\n<\/ul>\n<ul>\n<li>Improvement of<strong> pigment homogeneity.<\/strong><\/li>\n<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6e12ec8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6e12ec8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-84c28e4\" data-id=\"84c28e4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8635a93 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"8635a93\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-1024x768.jpg\" class=\"attachment-large size-large wp-image-12328\" alt=\"effet antioxydant - pigmentation\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-1536x1152.jpg 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00-2048x1536.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Source image<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fc643a9\" data-id=\"fc643a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc90f49 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"dc90f49\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-1024x768.jpg\" class=\"attachment-large size-large wp-image-12334\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-1536x1152.jpg 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_contour-2048x1536.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Lentigine detection<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3a51e32 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a51e32\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4ddac60\" data-id=\"4ddac60\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9a755ce elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9a755ce\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-1024x768.jpg\" class=\"attachment-large size-large wp-image-12332\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-1536x1152.jpg 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00Pig-2048x1536.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Artificial rendering<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a35321f\" data-id=\"a35321f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a3f18ca elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a3f18ca\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-1024x768.jpg\" class=\"attachment-large size-large wp-image-12330\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-1536x1152.jpg 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/67919_CCubeImage_p001_t00_z00_clahe-2048x1536.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Artificial rendering<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0de79ff elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0de79ff\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ea5b362\" data-id=\"ea5b362\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2940af8 elementor-widget elementor-widget-spacer\" data-id=\"2940af8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71cd266 elementor-widget elementor-widget-text-editor\" data-id=\"71cd266\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>2. Pollution: measurement of residual particles on the skin<\/strong><\/p>\n<p>The alteration of the skin barrier promotes the adhesion of polluting particles. To evaluate the barrier or detoxifying effect of an antioxidant treatment, the C-Cube quantifies the <strong>detoxifying or protective<\/strong> effect of antioxidant products via a <strong>residual pollution index.<\/strong> <\/p>\n<p>A standardized image is taken before and after particle deposition, and then after cleansing or application of the protective self. The analysis of the images with this <strong>particle index <\/strong>makes it possible to quantify the residual quantity and thus to evaluate the protective or cleaning effect of the product tested. <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d457cc2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d457cc2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-868048f\" data-id=\"868048f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-849819a elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"849819a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-1024x768.jpg\" class=\"attachment-large size-large wp-image-12336\" alt=\"effet antioxydant - pollution\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-1536x1152.jpg 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/CLD84-NON-TRAITEE-2048x1536.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Artificial rendering<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f39187e\" data-id=\"f39187e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d2674b4 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"d2674b4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2024\/10\/CLD84-TRAITEE-1-1024x768.jpg\" class=\"attachment-large size-large wp-image-10164\" alt=\"\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2024\/10\/CLD84-TRAITEE-1-1024x768.jpg 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2024\/10\/CLD84-TRAITEE-1-300x225.jpg 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2024\/10\/CLD84-TRAITEE-1-768x576.jpg 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2024\/10\/CLD84-TRAITEE-1.jpg 1100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Source image<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-deaf853 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"deaf853\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2faa976\" data-id=\"2faa976\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e7436b4 elementor-widget elementor-widget-spacer\" data-id=\"e7436b4\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a4f079 elementor-widget elementor-widget-text-editor\" data-id=\"4a4f079\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol start=\"3\">\n<li><strong> Skin roughness evaluation<\/strong><\/li>\n<\/ol>\n<p><strong> <\/strong><\/p>\n<p>Oxidative stress impacts collagen and elastin, accentuating the roughness of the skin. The 3D module of the C-Cube extracts several indicators that comply with the<strong> ISO 25178 standard:<\/strong> <\/p>\n<ul>\n<li><strong>Sa<\/strong> (average roughness),<\/li>\n<li><strong>Sq<\/strong> (quadratic roughness),<\/li>\n<li><strong>Sdr<\/strong> (Relative surface development).<\/li>\n<\/ul>\n<p>These quantitative data make it possible to finely measure the <strong>smoothing and restructuring effect <\/strong>of an antioxidant treatment, by comparing the condition of the skin relief before and after application.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c4e564 elementor-widget__width-initial e-transform elementor-widget elementor-widget-image\" data-id=\"2c4e564\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:219,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" width=\"800\" height=\"600\" src=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-1024x768.png\" class=\"attachment-large size-large wp-image-12338\" alt=\"effet antioxydant - rugosit\u00e9\" srcset=\"https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-1024x768.png 1024w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-300x225.png 300w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-768x576.png 768w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-1536x1152.png 1536w, https:\/\/www.pixience.com\/wp-content\/uploads\/2025\/06\/3D-roughness-sans-fond-2048x1536.png 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Rough skin example<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-073f251 elementor-widget elementor-widget-spacer\" data-id=\"073f251\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8efa5f5 elementor-widget elementor-widget-text-editor\" data-id=\"8efa5f5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>4.\u00a0 Radiance of the complexion: luminance index L*<\/strong><\/p><p>Oxidative stress is also responsible for a dullness of the complexion, often linked to an accumulation of dead cells, a decrease in skin vascularization or an overproduction of melanin. The expected effects of antioxidant skincare is therefore the <strong>improvement of radiance<\/strong>.<\/p><p>The C-Cube allows this effect to be measured quantitatively thanks to a brightness index based on the <strong>L*<\/strong> component of the <strong>CIE L*A*B*<\/strong> color space. This parameter represents the perceived luminance or brightness of a surface:<\/p><ul><li>An <strong>increase in L*<\/strong> indicates a gain in brightness,<\/li><li>A <strong>decrease <\/strong>reflects a duller complexion.<\/li><\/ul><p>Measurements are taken on calibrated images, under standardized conditions, guaranteeing a reliable comparison over time or between groups.<\/p><p>This parameter is valuable for &#8220;energy boost&#8221;, &#8220;anti-fatigue&#8221; or &#8220;instant radiance&#8221; treatments.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b386fd elementor-widget elementor-widget-spacer\" data-id=\"1b386fd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55ac599 elementor-widget elementor-widget-heading\" data-id=\"55ac599\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">A robust solution for validating antioxidant claims<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d1408e elementor-widget elementor-widget-text-editor\" data-id=\"3d1408e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The evaluation of antioxidant effects in dermocosmetics requires analysis methods that are <strong>sensitive<\/strong>, <strong>reproducible <\/strong>and scientifically sound<\/p>\n<p>The <strong>C-Cube Clinical Research<\/strong> is a central tool in the evaluation of the clinical effectiveness of antioxidant treatments. It makes it possible to <strong>visually and digitally translate<\/strong> complex biological effects into <strong>objective, standardised and reproducible data.<\/strong> <\/p>\n<p>Used for products based on <strong>vitamin C, E, niacinamide, polyphenols or plant extracts,<\/strong> it accompanies the scientific <strong>demonstration of the claimed effects,<\/strong> in a multi-criteria validation logic (pigmentation, radiance, texture, pollution).<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Evaluating the effectiveness of antioxidant treatments: the contribution of the C-Cube in clinical research Antioxidants &amp; oxidative stress: major cosmetic issues Antioxidants have become essential active ingredients in cosmetic formulas, especially for their protective effects against oxidative stress. This phenomenon, caused by an overproduction of free radicals (from pollution, UV rays or aging), is responsible [&hellip;]<\/p>\n","protected":false},"author":2129,"featured_media":12324,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[73],"tags":[74],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antioxidant effects - Pixience<\/title>\n<meta name=\"description\" content=\"Antioxidants are essential ingredients in cosmetic formulas. 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